A common genetic factor underlies hypertension and other cardiovascular disorders.
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How to cite this URL: Williams FM, Cherkas LF, Spector TD, MacGregor AJ.
How to cite this article: Williams FM, Cherkas LF, Spector TD, MacGregor AJ. The demonstration of a shared genetic factor explains the association between them and adds weight to the theory of an inherited predisposition to vasospasm. Multivariate model fitting demonstrated that a single common genetic factor underlies the four conditions.Ĭonclusions : We have confirmed an association between hypertension, migraine, Raynaud's phenomenon and coronary artery disease, and shown that a single genetic factor underlies them. There was a significant genetic contribution to all four traits with heritability ranging from 0.34 to 0.64.
Results : Responses were obtained from 2,204 individuals comprising 525 monozygotic and 577 dizygotic pairs. Phenotype status was determined using a questionnaire and the genetic and environmental association between phenotypes was estimated through variance components analysis. Methods : We investigated the association between hypertension, migraine, Raynaud's phenomenon and coronary artery disease in twins from a national register. This study used a classical twin design to examine whether these conditions are linked through shared environmental exposures or by a common underlying genetic propensity to vasospasm. However, the biological causes for these associations remain controversial.
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Additionally this is the only case where the 3rd placed act from the Public Vote won the Judges Vote and advanced onto the Final and the 2nd placed act from the Public Vote lost the Judges Vote and therefore missed out on the Final in Series 7.Background : Certain conditions characterized by blood vessel occlusion or vascular spasm, have been found to cluster together in epidemiological studies. Had Keirl have received two votes and sent the vote to deadlock he would have reached the Final rather than Asanda as he received 21.4% of the Public Vote and she received 19.4% of the Public Vote, therefore meaning she received 2% less votes in comparison to him.He received 1.8% of the Public Vote in comparison to Francine Lewis with Lewis receiving 23.2% of votes, and Keirl having received 21.4% of the votes as displayed by the Voting Figures.He was eliminated due to Alesha Dixon being the only judge to put him through, Simon Cowell, Amanda Holden, and David Walliams all voted for his opposition Asanda. Alex competed in semi final four, he got as far as the judges vote. He received a standing ovation from the audience. In the Semi-Final he sang 'First Time Ever I Saw Your Face' by by Roberta Flack. Simon Cowell however gave slight criticism believing his pitch may have been 'A little, too high.' He advanced through to the next round with four yesses Amanda Holden commented on the fact he had an 'extraordinary' breath control.
David Walliams commented that he had 'A really stunning voice' and 'really interpreted the song.' Alesha Dixon added he had 'A very, very powerful instrument' within his voice.
In his audition he sang 'Bring Him Home' by Josh Groban. He was aged twenty at the time of his audition. Alex Keirl was a singer who reached the Semi-Finals of Series 7 of Britain's Got Talent.
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